Thymidine diphosphate, abbreviated TDP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleosidethymidine. TDP consists of the pyrophosphategroup, the pentosesugarribose, and the nucleobasethymine. IUPAC nomenclature is a systematic way of naming organic chemical compounds as recommended by the International Union of Pure and Applied Chemistry (IUPAC). ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The simplified molecular input line entry specification or SMILES is a specification for unambiguously describing the structure of chemical molecules using short ASCII alpha-numeric strings. ... Download high resolution version (2954x1995, 15 KB) Wikipedia does not have an article with this exact name. ... A nucleotide is a monomer or the structural unit of nucleotide chains forming nucleic acids as RNA and DNA. A nucleotide consists of a heterocyclic nucleobase, a pentose sugar, and a phosphate or polyphosphate group. ... In organic chemistry and biochemistry esters are substances where an organic group replaces a hydrogen atom (or more than one) in an oxygen acid. ... Pyrophosphoric acid, also known under the name diphosphoric acid, is a syrupy liquid or a needle-like crystaline solid. ... Nucleosides are glycosylamines made by attaching a nucleobase to a ribose ring. ... Thymidine is a molecule (known as a nucleoside) that is formed when thymine is attached to a deoxyribose ring (also known as a deoxyribofuranose) via a β-N1-glycosidic bond. ... In chemistry, pyrophosphate, or PPi is an anion observed in living systems, usually formed by the hydrolysis of ATP into AMP. The hydrolysis is called pyrophosphorolysis. ... In ecology functional groups are collections of organisms based on morphological, physiological, behavioral, biochemical, or environmental responses or on trophic criteria. ... A pentose is a monosaccharide with five carbon atoms. ... A sugar is a carbohydrate which is sweet to taste. ... Ribose Ribose is a five carbon sugar (pentose) that is critical to living creatures. ... Nucleobases are the parts of RNA and DNA that are involved in pairing up (see also base pairs). ... Thymine, also known as 5-methyluracil, is a pyrimidine nucleobase. ...
Thymidine kinase TK, is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC 2.7.1.75.
The first indirect use of thymidine kinase in biochemical research was the identification of dividing cells by incorporation of radiolabeled thymidine and subsequent measurement of the radioactivity or autoradiography to identify the dividing cells.
The thymidine kinase level in serum therefore serves as a measure of malignant proliferation, indirectly as a measure of the aggressivity of the tumour.