Thymidine monophosphate, also known as 5'-thymidylic acid and abbreviated TMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleosidethymidine. TMP consists of the phosphategroup, the pentosesugarribose, and the nucleobasethymine. IUPAC nomenclature is a systematic way of naming organic chemical compounds as recommended by the International Union of Pure and Applied Chemistry (IUPAC). ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The simplified molecular input line entry specification or SMILES is a specification for unambiguously describing the structure of chemical molecules using short ASCII alpha-numeric strings. ... Download high resolution version (2346x1995, 12 KB) Wikipedia does not have an article with this exact name. ... A nucleotide is a monomer or the structural unit of nucleotide chains forming nucleic acids as RNA and DNA. A nucleotide consists of a heterocyclic nucleobase, a pentose sugar, and a phosphate or polyphosphate group. ... Ribonucleic acid (RNA) is a nucleic acid consisting of a string of covalently-bound nucleotides. ... In organic chemistry and biochemistry esters are substances where an organic group replaces a hydrogen atom (or more than one) in an oxygen acid. ... Phosphoric acid, also known as orthophosphoric acid or phosphoric(V) acid, is a weak mineral acid with the chemical formula H3PO4. ... Nucleosides are glycosylamines made by attaching a nucleobase to a ribose ring. ... Thymidine is a molecule (known as a nucleoside) that is formed when thymine is attached to a deoxyribose ring (also known as a deoxyribofuranose) via a β-N1-glycosidic bond. ... In chemistry, a phosphate is a polyatomic ion or radical consisting of one phosphorus atom and four oxygen. ... In ecology functional groups are collections of organisms based on morphological, physiological, behavioral, biochemical, or environmental responses or on trophic criteria. ... A pentose is a monosaccharide with five carbon atoms. ... A sugar is a carbohydrate which is sweet to taste. ... Ribose Ribose is a five carbon sugar (pentose) that is critical to living creatures. ... Nucleobases are the parts of RNA and DNA that are involved in pairing up (see also base pairs). ... Thymine, also known as 5-methyluracil, is a pyrimidine nucleobase. ...
Thymidine kinase TK, is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC 2.7.1.75.
The thymidine kinase level in serum therefore serves as a measure of malignant proliferation, indirectly as a measure of the aggressivity of the tumour.
The monophosphate of iododeoxyuridine is adsorbed on aluminium oxide that is suspended in the incubation medium.
The accepted structure of the thymine molecule was published in 1900; this structure was confirmed when several investigators reported the synthesis of the compound during the period 1901 to 1910.
Combined with the sugardeoxyribose in a glycosidic linkage, thymine forms a derivative called thymidine (a nucleoside), which in turn can be phosphorylated with from one to three phosphoric acid groups, yielding respectively the three nucleotides TMP (thymidinemonophosphate), TDP (thymidine diphosphate), and TTP (thymidine triphosphate).
Thymidine is significant because of its involvement in the biosynthesis of DNA and in the preservation and transfer of genetic information.
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