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Encyclopedia > Thyroid cancer
Thyroid cancer
Classification and external resources
ICD-10 C73.
ICD-9 193
eMedicine ent/646 
MeSH D013964

Thyroid cancer refers to any of four kinds of malignant tumors of the thyroid gland: papillary, follicular, medullary and anaplastic. Papillary and follicular tumors are the most common: they grow slowly, may recur, but are generally not fatal in patients under 45 years of age. Medullary tumors have a good prognosis if restricted to the thyroid gland and a poorer prognosis if metastasis occurs. Anaplastic tumors are fast-growing and respond poorly to therapy. The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization (WHO). ... // C00-D48 - Neoplasms (C00-C14) Malignant neoplasms, lip, oral cavity and pharynx (C00) Malignant neoplasm of lip (C01) Malignant neoplasm of base of tongue (C02) Malignant neoplasm of other and unspecified parts of tongue (C03) Malignant neoplasm of gum (C04) Malignant neoplasm of floor of mouth (C05) Malignant neoplasm of... The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. ... eMedicine is an online clinical medical knowledge base that was founded in 1996. ... Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ... Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ... For malignant tumors specifically, see cancer. ... Thyroid cancer is cancer of the thyroid gland. ... Thyroid cancer is cancer of the thyroid gland. ... For the musical composition, see Metastasis (Xenakis composition). ...


Thyroid nodules are diagnosed by ultrasound guided fine needle aspiration (USG/FNA) or frequently by thyroidectomy (surgical removal and subsequent histological examination). As thyroid cancer can take up iodine, radioactive iodine is commonly used to treat thyroid carcinomas, followed by TSH suppression by thyroxine therapy. In medicine, a nodule refers to a small aggregation of cells. ... Needle aspiration biopsy is a procedure performed to diagnose and treat certain kind of illnesses. ... A thyroidectomy involves the surgical removal all or part of the thyroid gland. ... For other uses, see Iodine (disambiguation). ... Iodine-131, also called radioiodine, is a radioisotope of iodine. ... Thyroid-stimulating hormone (also known as TSH or thyrotropin) is a hormone produced by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. ... Thyroxine, or 3:5,3:5 tetra­iodothyronine (often abbreviated as T4) is the major hormone secreted by the follicular cells of the thyroid gland. ...

Contents

Symptoms

Most often the first symptom of thyroid cancer is a nodule in the thyroid region of the neck. However, many adults have small nodules in their thyroids. But typically under 5% of these nodules are found to be malignant. Sometimes the first sign is an enlarged lymph node. Later symptoms that can be present are pain in the anterior region of the neck and changes in voice.


Thyroid cancer is usually found in a euthyroid patient, but hyperthyroidism may be a symptom of a large or metastatic well-differentiated tumor. The state of having normal thyroid gland function. ... Hyperthyroidism (or overactive thyroid gland) is the clinical syndrome caused by an excess of circulating free thyroxine (T4) or free triiodothyronine (T3), or both. ...


Nodules should be of particular concern when they are found in children or those under the age of 20. The presentation of benign nodules at this age is less likely, and thus the potential for malignancy is far greater. A nodule describes similar aggregation of cells or particles in a number of scientific fields: In medicine it refers to a small aggregation of cells. ...


Diagnosis

After a nodule is found during a physical examination, a referral to an endocrinologist, or a thyroidologist is the best approach. Most commonly an ultrasound is performed to confirm the presence of a nodule, and assess the status of the whole gland. Measurement of thyroid stimulating hormone and anti-thyroid antibodies will help decide if there is a functional thyroid disease such as Hashimoto's thyroiditis present, a known cause of a benign nodular goiter. [1] A nodule describes an aggregation of similar cells or particles in a number of scientific fields: In medicine it refers to a small aggregation of cells. ... Endocrinology is a branch of medicine dealing with disorders of the endocrine system and its specific secretions called hormones. ... For other uses, see Ultrasound (disambiguation). ... Thyroid-stimulating hormone (also known as TSH or thyrotropin) is a hormone produced by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. ... Hashimotos thyroiditis or chronic lymphocytic thyroiditis is an autoimmune disease where the bodys own antibodies attack the cells of the thyroid. ...


Fine needle biopsy

One approach used to determine whether the nodule is malignant is the fine needle biopsy (FNB)[2], which some have described as the most cost-effective, sensitive and accurate test.[citation needed] FNB or ultrasound-guided FNA usually yields sufficient thyroid cells to assess the risk of malignancy, although in some cases, the suspected nodule may need to be removed surgically for pathological examination.


Rarely, a biopsy is done using a large cutting needle, so that the a piece of nodule capsule can be obtained.


Blood tests

Blood or imaging tests may be done prior to or in lieu of a biopsy. The possibility of a nodule which secretes thyroid hormone (which is less likely to be cancer) or hypothyroidism is investigated by measuring thyroid stimulating hormone (TSH), and the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroid-stimulating hormone (also known as TSH or thyrotropin) is a hormone produced by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. ... Thyroxine, or 3:5,3:5 tetra­iodothyronine (often abbreviated as T4) is the major hormone secreted by the follicular cells of the thyroid gland. ... The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. ...


Tests for serum thyroid autoantibodies are sometimes done as these may indicate autoimmune thyroid disease (which can mimic nodular disease). Wikipedia does not yet have an article with this exact name. ... Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. ...


Imaging

The blood assays may be accompanied by ultrasound imaging of the nodule to determine the position, size and texture, and to assess whether the nodule may be cystic (fluid filled). Also suspicious findings in a nodule are hypoechoic,[3] irregular borders, microcalcifications, or very high levels of blood flow within the nodule. Less suspicious findings in benign nodules include, hyperechoic, comet tail artifacts from colloid, no blood flow in the nodule and a halo, or smooth border. Sonography redirects here. ... A cyst (soft c, rhymes with list) is a cloed sac having a distinct membrane and division on the nearby tissue. ... A Colloid or colloidal dispersion is a type of homogeneous mixture. ...


Some clinicians will also request technetium (Tc) or radioactive iodine (I) imaging of the thyroid. An 123I scan showing a hot nodule, accompanied by a lower than normal TSH, is strong evidence that the nodule is not cancerous. General Name, Symbol, Number technetium, Tc, 43 Chemical series transition metals Group, Period, Block 7, 5, d Appearance silvery gray metal Standard atomic weight [98](0) g·mol−1 Electron configuration [Kr] 4d5 5s2 Electrons per shell 2, 8, 18, 13, 2 Physical properties Phase solid Density (near r. ... For other uses, see Iodine (disambiguation). ... Nuclear medicine is the branch of medicine that uses unsealed radioactive substances in diagnosis and therapy. ... For other uses, see Iodine (disambiguation). ...


Classification

Thyroid cancers can be classified according to their pathological characteristics.[4][5] The following variants can be distinguished (distribution over various subtypes may show regional variation):

The follicular and papillary types together can be classified as "differentiated thyroid cancer".[7] These types have a more favorable prognosis than the medullary and undifferentiated types.[8] Thyroid cancer is cancer of the thyroid gland. ... Thyroid cancer is cancer of the thyroid gland. ... This article is about lymphoma in humans. ... Biopsy of a highly differentiated squamous cell carcinoma of the mouth. ... A sarcoma is a cancer of the connective or supportive tissue (bone, cartilage, fat, muscle, blood vessels) and soft tissue. ...


References

  1. ^ Bennedbaek FN, Perrild H, Hegedüs L (1999). "Diagnosis and treatment of the solitary thyroid nodule. Results of a European survey". Clin. Endocrinol. (Oxf) 50 (3): 357–63. PMID 10435062. 
  2. ^ Ravetto C, Colombo L, Dottorini ME (2000). "Usefulness of fine-needle aspiration in the diagnosis of thyroid carcinoma: a retrospective study in 37,895 patients". Cancer 90 (6): 357–63. PMID 11156519. 
  3. ^ Wong KT, Ahuja AT (2005). "Ultrasound of thyroid cancer". Cancer Imaging 5: 157–66. doi:10.1102/1470-7330.2005.0110. PMID 16361145. 
  4. ^ Thyroid Cancer Treatment - National Cancer Institute. Retrieved on 2007-12-22.
  5. ^ Thyroid cancer. Retrieved on 2007-12-22.
  6. ^ Schlumberger M, Carlomagno F, Baudin E, Bidart JM, Santoro M (2008). "New therapeutic approaches to treat medullary thyroid carcinoma". Nat Clin Pract Endocrinol Metab 4 (1): 22–32. doi:10.1038/ncpendmet0717. PMID 18084343. 
  7. ^ Nix P, Nicolaides A, Coatesworth AP (2005). "Thyroid cancer review 2: management of differentiated thyroid cancers". Int. J. Clin. Pract. 59 (12): 1459–63. doi:10.1111/j.1368-5031.2005.00672.x. PMID 16351679. 
  8. ^ Nix PA, Nicolaides A, Coatesworth AP (2006). "Thyroid cancer review 3: management of medullary and undifferentiated thyroid cancer". Int. J. Clin. Pract. 60 (1): 80–4. doi:10.1111/j.1742-1241.2005.00673.x. PMID 16409432. 

A digital object identifier (or DOI) is a standard for persistently identifying a piece of intellectual property on a digital network and associating it with related data, the metadata, in a structured extensible way. ... Year 2007 (MMVII) was a common year starting on Monday of the Gregorian calendar in the 21st century. ... is the 356th day of the year (357th in leap years) in the Gregorian calendar. ... Year 2007 (MMVII) was a common year starting on Monday of the Gregorian calendar in the 21st century. ... is the 356th day of the year (357th in leap years) in the Gregorian calendar. ... A digital object identifier (or DOI) is a standard for persistently identifying a piece of intellectual property on a digital network and associating it with related data, the metadata, in a structured extensible way. ... A digital object identifier (or DOI) is a standard for persistently identifying a piece of intellectual property on a digital network and associating it with related data, the metadata, in a structured extensible way. ... A digital object identifier (or DOI) is a standard for persistently identifying a piece of intellectual property on a digital network and associating it with related data, the metadata, in a structured extensible way. ...

See also

Chernobyl reactor number four after the disaster, showing the extensive damage to the main reactor hall (image center) and turbine building (image lower left) The Chernobyl disaster, reactor accident at the Chernobyl nuclear power plant, or simply Chernobyl, was the worst nuclear power plant accident in history and the only... The radiation warning symbol (trefoil). ...

External links

Thyroid cancer is cancer of the thyroid gland. ... Thyroid cancer is cancer of the thyroid gland. ... Adrenocortical carcinoma is a carcinoma of the cortex (outer layer) of the adrenal gland. ... A phaeochromocytoma (pheochromocytoma in the US) is a neuroendocrine tumor of the medulla of the adrenal glands originating in the chromaffin cells, which secretes excessive amounts of catecholamines, usually adrenaline and noradrenaline (epinephrine and norepinephrine in the US). ... Pituitary adenomas are tumors that occur in the pituitary gland, and account for about 10% of intracranial neoplasms. ... A tumor suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. ... An oncogene is a modified gene that increases the malignancy of a tumor cell. ... The stage of a cancer is a descriptor (usually numbers I to IV) of how much the cancer has spread. ... In pathology, Grading is a measure of the progress of tumors. ... Cancers are caused by a series of mutations. ... Look up carcinogen in Wiktionary, the free dictionary. ... Cancer research is research into cancer in order to identify causes and develop strategies for prevention, diagnosis, treatments and cure. ... A paraneoplastic phenomenon is a disease or symptom that is the consequence of the presence of cancer in the body, but is not due to the local presence of cancer cells. ... This is a list of terms related to oncology. ...

  Results from FactBites:
 
Thyroid.org: Cancer of the Thyroid Brochure (1533 words)
Thyroid cancer is more common in people who have a history of exposure of the thyroid gland to radiation, have a family history of thyroid cancer, and are older than 40 years of age.
Thyroid cancer can be caused by absorbing radioactive iodine released during a nuclear power plant emergency, such as the 1986 nuclear accident at the Chernobyl power plant in Russia.
If the cancer is large within the thyroid or if it has spread to lymph nodes or if your doctor feels that you are at high risk for recurrent cancer, radioactive iodine can be used as a “magic bullet” to destroy thyroid cancer cells after removal of the thyroid gland by surgery.
Thyroid Cancer (5499 words)
Thyroid cancer was first described by Halsted in his extensive compilation of documented thyroidectomies by the terms sarcomatous degeneration, thyroid tumor or thyroid cancer cells.
Thyroid cancers are classified by their predominant histologic cell types, as follow:  (1) well-differentiated malignant neoplasm (WDTC) accounts for 85% of thyroid cancers, including papillary, follicular, and Hurthle cell carcinomas, and (2) more aggressive variants include medullary carcinoma and anaplastic carcinoma (3) other tumors including lymphomas and metastatic tumors.
Patterns of calcification on chest x-ray are useful in identifying the types of cancer: (1) rim or eggshell calcification suggests a benign lesion, (2) bilateral calcification in superolateral aspect of the thyroid gland indicates MTC and (3) extensive irregular calcification suggests a multinodular goiter.
  More results at FactBites »


 

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