Thyroid peroxidase is an enzyme (EC 1.11.1.8 mainly expressed in the thyroid that liberates iodine for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (thyroid hormone). This process is termed the "organification of iodine". Ribbon diagram of the catalytically perfect enzyme TIM. Factor D enzyme crystal prevents the immune system from inappropriately running out of control. ... EC numbers (Enzyme Commission numbers) are a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... General Name, Symbol, Number iodine, I, 53 Chemical series halogens Group, Period, Block 17, 5, p Appearance violet-dark gray, lustrous Atomic mass 126. ... Tyrosine (from the Greek tyros, meaning cheese, as it was first discovered in cheese), 4-hydroxyphenylalanine, or 2-amino-3(4-hydroxyphenyl)-propanoic acid, is one of the 20 amino acids that are used by cells to synthesize proteins. ... Thyroglobulin is a protein secreted by the thyroid gland. ... The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. ...
It is inhibited by the thioamide drugs, such as propylthiouracil. It is a frequent epitope of autoantibodies in autoimmune thyroid disease. Thioamides are a group of drugs used to control thyrotoxicosis. ... Propylthiouracil is a a drug used to treat hyperthyroidism. ... An autoantibody is a protein manufactured by the immune system that is directed against one or more of the hosts own proteins. ...
Thyroid functional disorders and autoimmune thyroid diseases have been reported in association with vitiligo and it seems that the incidence of clinical and subclinical thyroid involvement is more common in vitiligo patients than healthy subjects [2].
Thyroidperoxidase is responsible for the iodination of tyrosine residues in the thyroglobulin molecule.
Shong YK, Kim JA: Vitiligo in autoimmune thyroid disease.
With the general hyperactivity of the thyroid, excess TG is released and serum TG levels are elevated in active Graves' disease.
An important abnormality in thyroid function during Graves' disease is that the uptake of 131I by the thyroid is not suppressed by administration of exogenous T4 or T3 (119,120).
This abnormal response to the administration of thyroid hormone occurs in spite of responsiveness of the thyroid to administered exogenous TSH, as measured by augmented release of thyroid hormone.
Feeds |
Contact