Tonawanda Creek is a small river in Western New York, in the United States. Tonawanda Creek rises in Wyoming County and enters the Niagara River between Niagara County and Erie County, forming a boundary between them. Tonawanda Creek passes through the Village of Attica, the City of Batavia, and flows past the City of Tonawanda and the City of North Tonawanda before entering the Niagara River.

The length of Tonawanda Creek is 145 kilometers, and it has a meandering course for most of its length.

During the spring of each year, Tonawanda Creek floods to varying degrees. These floods are more of an inconvenience than a danger, but can occasionally cause heavy property damage along inhabited sections of its course.

Tonawanda Creek is also part of the Erie Canal, which joins the creek southwest of Lockport and allows canal traffic to proceed into the Niagara River.