Total Body Irradiation (TBI) is a radiotherapy technique used to ablate the bone marrow and immune system prior to bone marrow transplantation or peripheral blood stem cell transplantation. It may be used as part of high-dose treatment of some leukaemias and lymphomas. The aim of this type of ablative therapy is to prevent rejection of the transplanted cells. Radiation therapy (or radiotherapy) is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis). ... Ablation is defined as the removal of material from the surface of an object by vaporization, chipping, or other erosive processes. ... Grays Anatomy illustration of cells in bone marrow. ... The immune system protects the host from infection by pathogenic organisms. ... Bone marrow transplantation (BMT) or hematopoietic stem cell transplantation (HSCT) is a medical procedure in the field of hematology and oncology that involves transplantation of hematopoietic stem cells (HSC). ... Leukemia (leukaemia in Commonwealth English) is a group of blood diseases characterized by malignancies (cancer) of the blood-forming tissues. ... To meet Wikipedias quality standards, this article may require cleanup. ... Transplant rejection occurs when the immune system of the recipient of a transplant attacks the transplanted organ or tissue. ...
During TBI the whole body is irradiated to between 9 to 14 Gy, a dose which, though modest by normal radiotherapy standards (when restricted to a small portion of the body, usually the tumor site,) would be lethal when absorbed by the entire body, were rescue with the transplant not to follow directly. The gray (symbol: Gy) is the SI unit of absorbed dose. ...
TotalBodyIrradiation (TBI) is a radiotherapy technique used to ablate the bone marrow and immune system prior to bone marrow transplantation or peripheral blood stem cell transplantation.
The aim of this type of ablative therapy is to prevent rejection of the transplanted cells.
During TBI the whole body is irradiated to approximately 9 Gy, a dose which, though modest by normal radiotherapy standards (when restricted to a small portion of the body, usually the tumor site,) would be lethal when absorbed by the entire body, were rescue with the transplant not to follow directly.
Totalbodyirradiation (TBI) is used at Columbia University Medical Center as part of the conditioning regimen prior to allogeneic bone marrow transplantation for leukemias and lymphomas.
Totalbodyirradiation aids in the engraftment, or acceptance, of these foreign immune cells by the body.
Better supportive care, refinements and improvements in totalbodyirradiation technique and chemotherapy regimens, and better understanding and application of immune cell therapeutics will all contribute to the more effective management of selected patients with leukemias and lymphomas.
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