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Encyclopedia > Transporter associated with antigen processing
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
Symbol TAP1 ABCB2
HUGO 43
Entrez 6890
OMIM 170260
RefSeq NM_000593
UniProt Q03518
Other data
Locus Chr. 6 p21.3
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
Symbol TAP2 ABCB3
HUGO 44
Entrez 6891
OMIM 170261
RefSeq NM_000544
UniProt Q03519
Other data
Locus Chr. 6 p21.3

Transporter associated with antigen processing (TAP) is a member of the ATP-binding-cassette transporter family (ABC transporter).[1] It delivers cytosolic peptides into the endoplasmic reticulum (ER) where they bind to nascent MHC class I molecules. [2] Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 6 is one of the 23 pairs of chromosomes in humans. ... Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 6 is one of the 23 pairs of chromosomes in humans. ... The ATP-binding cassette (ABC) transporter superfamily of membrane proteins function in the transport of a wide variety of substrates across extra- and intracellular membranes, including metabolic products, lipids and sterols, and drugs. ... The endoplasmic reticulum or ER is an organelle found in all eukaryotic cells that is an interconnected network of tubules, vesicles and cisternae that is responsible for several specialized functions: Protein translation, folding, and transport of proteins to be used in the cell membrane (e. ... MHC class I molecules are cell surface proteins found on most cells of the body. ...


Tapasin may also have a role in stablising "empty" MHC class 1 molecules (i.e. those without peptides destined for presentation), epitope selection and quality control after peptide binding.


References

  1. ^ Daumke, O. (2001) Functional asymmetry of the ATP-binding-cassettes of the ABC transporter TAP is determined by intrinsic properties of the nucleotide binding domains. Eur. J. Biochem., 268:4776-4786.
  2. ^ Suh, WK. (1994) Interaction of MHC class I molecules with the transporter associated with antigen processing. Science. Vol 264 5163:1322-1326.

External links



 

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