Tropane (C8H15N, 8-methyl-8-aza-bicyclo[3.2.1]octane) is a nitrogenous bicyclic organic compound. It is mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine. Tropane alkaloids occur in plants of the families Solanaceae (mandrake, henbane, deadly nightshade, Datura species) and Erythroxylaceae (coca). Image File history File links Download high resolution version (1263x1837, 10 KB) * Description: Chemical structure of tropane. ... Image File history File links Download high resolution version (1263x1837, 10 KB) * Description: Chemical structure of tropane. ... An organic compound is any member of a large class of chemical compounds whose molecules contain carbon, with exception of carbides, carbonates and carbon oxides. ... An alkaloid is a nitrogenous organic molecule that has a pharmacological effect on humans and other animals. ... Structure of atropine (hyoscyamine) Atropine is an alkaloid extracted from the deadly nightshade (Atropa belladonna) and other plants of the family Solanaceae. ... Cocaine is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. ... Genera Acnistus Atropa (deadly nightshade) Brugmansia (angels trumpet) Calibrachoa Capsicum (chile peppers) Datura (jimsonweed) Hyoscyamus (henbane) Iochroma Lycium (boxthorn) Lycopersicon (tomato) Mandragora (mandrake) Nicandra Nicotiana (tobacco) Petunia Physalis (tomatillo) Solandra Solanum (potato, eggplant) Streptosolen For more genera see Solanaceae in The Families of Flowering Plants Wikispecies has information on... Species Mandragora autumnalis Mandragora officinarum Mandragora turcomanica Mandragora caulescens Mandrake is the common name for members of the plant genus Mandragora belonging to the nightshades family (Solanaceae). ... Binomial name Hyoscyamos niger Henbane (Hyoscyamos niger) is a plant of the family Solanaceae that originated in Eurasia. ... Binomial name Atropa belladonna L. Deadly nightshade or belladonna (Atropa belladonna) is a well-known, hardy perennial shrub, a member of the nightshade family. ... Species see text Datura is a genus of herb and shrub plants belonging to the Solanaceae. ... Binomial name Erythroxylon coca For the American comedian, see Imogene Coca. ...
8-aza-bicyclo[3.2.1]octane (tropane without the 8-methyl group) is known as nortropane or nor-tropane.
References
"Atropine content of plants". USDA, ARS, National Genetic Resources Program. Phytochemical and Ethnobotanical Databases. [Online Database] National Germplasm Resources Laboratory, Beltsville, Maryland. URL accessed on July 25, 2005.
"Cocaine content of plants". USDA, ARS, National Genetic Resources Program. Phytochemical and Ethnobotanical Databases. [Online Database] National Germplasm Resources Laboratory, Beltsville, Maryland. URL accessed on July 25, 2005.
The invention relates to a pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof, and at least one dopamine agonist or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof.
Accordingly, the invention relates to a pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof, and at least one NMDA receptor antagonists or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof.
The invention relates to a pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor comprising a 2,3-disubstituted tropane moiety, or a tautomer, a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof, and at least one acetylcholinesterase inhibitor or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof, and a...
One of the most biologically active groups of compounds to which the new synthesis method is being applied are the tropanes, which show very high selectivity in their interaction with various regions of the brain.
Efforts to develop a chemical treatment for addiction to cocaine, which is a tropane, have been hampered in the past by the lack of a reliable synthetic method.
However, many existing methods of synthesizing tropanes and other biologically important chemicals produce an equal mixture of the two isomers.
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