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Encyclopedia > Trousseau's sign

Trousseau sign is the name of two distinct phenomena observed in clinical medicine. Both are attributed to Armand Trousseau:


Trousseau sign of latent tetany

It has been suggested that this article or section be merged with Carpopedal spasm. (Discuss)

In a patient with hypocalcemia, carpal spasm may be elicited by occluding the brachial artery. To perform the maneuver, a blood pressure cuff is placed around the arm and inflated to a pressure greater than the systolic blood pressure and held in place for 3 minutes. If carpal spasm occurs, manifested as flexion at the wrist and metacarpophalangeal joints, extension of the distal interphalangeal and proximal interphalangeal joints, and adduction of the thumb and fingers, the sign is said to be positive and the patient likely has hypocalcemia. This sign may become positive before other gross manifestations of hypocalcemia such as hyperreflexia and tetany, but is generally believed to be less sensitive than the Chvostek sign for hypocalcemia. Wikipedia does not have an article with this exact name. ... In medicine, hypocalcaemia is the presence of less than a total calcium of 2. ... In human anatomy, the carpal bones are the bones of the human wrist. ... Hyperreflexia is defined as overactive or overresponsive reflexes. ... Tetany is the point at which signals from nerves (action potentials) are arriving to skeletal muscle rapidly enough in succession to cause a steady contraction, and not just a series of individual twitches. ...


Trousseau sign of malignancy

Referred to as "Trousseau's syndrome" to distinguish it from the above.


Some malignancies, especially adenocarcinomas of the pancreas and lung, are associated with hypercoaguability for reasons that remain unclear. In patients with malignancy-associated hypercoaguable states, the blood may sponteneously form clots in the portal vessels, the deep veins of the extremities, or the superficial veins anywhere on the body. When recurrent clots form in different superficial veins around the body, this is described as migratory thrombophlebitis. Dr. Armand Trousseau first described this finding in himself; he was subsequently found to have pancreatic cancer. In medicine, carcinoma is any cancer that arises from epithelial cells. ... The pancreas is an organ that serves two functions: exocrine - it produces pancreatic juice containing digestive enzymes. ... The lungs flank the heart and great vessels in the chest cavity. ...


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