Tubocurarine chloride is a competitive neuromuscular blocker, used to paralyse patients undergoing anaesthesia. It is one of the chemicals that can be obtained from curare, itself an extract of Chondodendron tomentosum, a plant found in South American jungles which is used as a source of arrow poison. Image File history File links Download high resolution version (1011x510, 14 KB) Summary Chemical structure of tubocurarine chloride created with ChemDraw. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass (abbreviated MM) of a substance, called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The melting point of a solid is the temperature at which it changes state from solid to liquid. ... Anesthesia (AE), also anaesthesia (BE), is the process of blocking the perception of pain and other sensations. ... Strychnos toxifera by Koehler 1887 Curare is a substance containing the alkaloid D-tubocurarine. ... South America South America is a continent crossed by the equator, with most of its area in the Southern Hemisphere. ...
The correct chemical structure was only elucidated circa 1970, even though the plant had been known since the Spanish Conquest.
The word curare comes from the South American Indian name for the arrow poison: "ourare". Presumably the initial syllable was pronounced with a heavy glottal stroke. Tubocurarine is so called because the plant samples containing it were first shipped to Europe in tubes.
Today, tubocurarine has fallen into disuse in western medicine, as safer synthetic alternatives such as atracurium besilate are available. See drugs, medication, and pharmacology for substances that are used to treat patients. ...
The large influx of potassium ions interrupts the wave of depolarization (action potential) to the heart muscle resulting in cardiac arrest.
A paralyzing agent, such as pancuronium bromide or tubocurarine chloride, plus a lethal dosage of a general anesthetic, such as sodium thiopental (sodium pentothal) are usually given before the potassium chloride is administered.
Tubocurarine is the active ingredient of curare, an extract from the bark and stems of the South American vine (Chondodendron tomentosum).
Patients receiving lasix drug high doses of salicylates concomitantly with furosemide, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.
Furosemide has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine.
Lithium generally lasix drug should not be given with diuretics because they reduce lithium's renal clearance and add a high risk of lithium toxicity.
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