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Encyclopedia > Type I keratin

Type I keratins (or Type I cytokeratins) constitutes the Type I intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. Most of the type I cytokeratins consist of acidic, low molecular weight proteins which 'in vivo' are arranged in pairs of heterotypic Type I and Type II keratin chains, coexpressed during differentiation of simple and stratified epithelial tissues. Intermediate filaments are one component of the cytoskeleton - important structural components of living cells. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...


Type I cytokeratins are encoded on chromosome 17q and encompasses: CK9, CK10, CK11, CK12, CK13, CK14, CK15, CK16, CK17, CK18, CK19 and CK20. Their molecular weight ranges from 40 kDa (CK19) to 64 kDa (CK9).


External links

  • MeSH Type+I+Keratin

  Results from FactBites:
 
keratin on Encyclopedia.com (349 words)
The keratins are the major protein components of hair, wool, nails, horn, hoofs, and the quills of feathers.
Structural-mechanical integration of keratin intermediate filaments with cell peripheral structures in the cornified epidermal keratinocyte.
Type I keratin 16 forms relatively unstable tetrameric assembly subunits with various type II keratin partners: biochemical basis and functional implications.
  More results at FactBites »


 

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