Typical antipsychotics (sometimes referred to as conventional antipsychotics or conventional neuroleptics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia), and are generally being replaced by atypical antipsychotic drugs. Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions. The term antipsychotic is applied to a group of drugs used to treat psychosis. ... 1950 (MCML) was a common year starting on Sunday (link will take you to calendar). ... This article is about the mental state. ... The atypical antipsychotics (also known as second generation antipsychotics) are a class of prescription medications used to treat psychiatric conditions. ...

Traditional antipsychotics are broken down into low-potency and high-potency classifications. Fluphenazine and haloperidol are examples of high-potency typical antipsychotics, and chlorpromazine is an example of a low potency antipsychotic. High-potency typical antipsychotics tend to be associated with more extrapyramidal side-effects (EPS) and less histaminic (e.g. sedation), alpha adrenergic (e.g. orthostasis) and anticholinergic (e.g. dry mouth) side effects, while low-potency typical antipsychotics tend to be associated with less EPS but more H1, alpha1, and muscarinic side effects. Fluphenazineis a typical antipsychoticdrug. ... Haloperidol (Aloperidin®; Bioperidolo®; Brotopon®; Dozic®; Einalon S®; Eukystol®; Haldol®; Halosten®; Keselan®; Linton®; Peluces®; Serenace®; Serenase®; Sigaperidol®) is a conventional butyrophenone antipsychotic drug. ... Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. ... In human anatomy, the extrapyramidal system is a neural network located in the brain that is part of the motor system involved in the coordination of movement. ...

Depot injections

Some of the high-potency antipsychotics, particularly haloperidol and fluphenazine, have been formulated as the decanoate ester (e.g. fluphenazine decanoate) to allow for a slow release of the active drug when given as a deep, intramuscular injection. This has the advantage of providing reliable dosing for a person who has trouble with compliance. Depot injections can also be used for involuntary community treatment patients to ensure compliance with a community treatment order when the patient would refuse to take daily oral medication. For practical reasons, depot preparations are limited to high-potency antipsychotics so the treating physician has a limited choice. It is therefore preferable to use oral medications if the cooperation and compliance of the patient can be obtained. Haloperidol (Aloperidin®; Bioperidolo®; Brotopon®; Dozic®; Einalon S®; Eukystol®; Haldol®; Halosten®; Keselan®; Linton®; Peluces®; Serenace®; Serenase®; Sigaperidol®) is a conventional butyrophenone antipsychotic drug. ... Fluphenazineis a typical antipsychoticdrug. ... Fluphenazineis a typical antipsychoticdrug. ... Outpatient commitment refers to mental health law which allows the compulsory, community-based treatment of individuals with mental illness. ...

Common side-effects

Side effects vary among the various agents in this class of medications, but common side effects include: dry mouth, muscle stiffness, muscle cramping, tremors, EPS and weight-gain. EPS is a cluster of symptoms consisting of parkinsonism, dystonias, and akathisia. Anticholinergics such as benztropine and diphenhydramine are commonly prescribed to treat the symptoms of EPS. A top-down view of skeletal muscle Muscle is a contractile form of tissue. ... Tremor is the rhythmic, oscillating shaking movement of the whole body or just a certain part of it, caused by problems of the neurons responsible from muscle action. ... In human anatomy, the extrapyramidal system is a neural network located in the brain that is part of the motor system involved in the coordination of movement. ... In the physical sciences, weight is the downward force exerted on matter as a result of gravity. ... Parkinsons disease (PD; paralysis agitans) is a neurodegenerative disease of the substantia nigra (an area in the basal ganglia). ... Dystonia (literally, abnormal muscle tone) is a generic term used to describe a neurological movement disorder involving involuntary, sustained muscle contractions. ... Akathisia (or acathisia) is an often extremely unpleasant subjective sensation of inner restlessness that manifests itself with an inability to sit still or remain motionless, hence the origin of its name: Greek a (without) + kithesia (to sit). ... Benztropine (Cogentin) is an anticholinergic drug used to treat muscle-rigidity, restlessness, and stiffness. ... Diphenhydramine hydrochloride (trade name Benadryl®, or Dimedrol outside the US) is an over-the-counter (OTC) antihistamine and sedative. ...

Risks of serious side-effects

There is a significant risk of the serious condition tardive dyskinesia developing as a side-effect of typical antipsychotics. The risk of developing tardive dyskinesia after chronic typical antipsychotic usage varies on several factors, such as age and gender. The commonly reported incidence of TD among younger patients is about 5% per year. Among older patients incidence rates as high than 20% per year have been reported. The average prevalence is approximately 30% [1]. There are no treatments that have consistently been shown to be effective for the treatment of tardive dyskinesias, however branched chain amino acids, melatonin, and vitamin E have been suggested as possible treatments. The atypical antipsychotic clozapine has also been suggested as an alternative antipsychotic for patients experiencing tardive dyskinesia. Tardive dyskinesia may reverse upon discontinuation of the offending agent or it may be irreversible. Tardive dyskinesia is a serious neurological disorder caused by the long-term use of traditional or typical antipsychotic drugs. ... In chemistry, an amino acid is any molecule that contains both amino and carboxylic acid functional groups. ... Clozapine (trade names Clozaril®; Leponex®; Fazaclo®), approved by the FDA in 1989, was the first of the atypical antipsychotics. ...

Neuroleptic malignant syndrome, or NMS, is a rare, but potentially fatal side effect of antipsychotic treatment. NMS is characterized by fever, muscle rigidity, autonomic dysfunction, and altered mental status. Treatment includes discontinuation of the offending agent and supportive care. Neuroleptic malignant syndrome (NMS) is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. ...

The role of typical antipsychotics has come into question recently as studies have suggested that atypical antipsychotics may increase the risk of death in elderly patients. A retrospective cohort study from the New England Journal of Medicine on Dec. 1, 2005 showed an increase in risk of death with the use of typical antipsychotics that was on par with the increase shown with atypical antipsychotics. This has led some to question the common use of antipsychotics for the treatment of agitation in the elderly, particularly with the availability of alternatives such as mood stabilizing and antiepileptic drugs.

Typical medications

• Chlorpromazine
• Fluphenazine (Prolixin^®)
• Haloperidol (Haldol^®)
• Molindone
• Thiothixene
• Thioridazine (Mellaril^®)
• Trifluoperazine
• Loxapine
• Perphenazine
• Prochlorperazine
• Pimozide

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. ... Fluphenazineis a typical antipsychoticdrug. ... Haloperidol (Aloperidin®; Bioperidolo®; Brotopon®; Dozic®; Einalon S®; Eukystol®; Haldol®; Halosten®; Keselan®; Linton®; Peluces®; Serenace®; Serenase®; Sigaperidol®) is a conventional butyrophenone antipsychotic drug. ... Thiothixene is an antipsychotic drug of the conventional or typical antipsychotics class. ... Thioridazine is a piperidine phenothiazine antipsychotic drugs and is used in the treatment of schizophrenia and psychosis. ... Trifluoperazine (Eskazinyl®, Eskazine®, Jatroneural®, Modalina®, Stelazine®, Terfluzine®) is a typical antipsychotic drug of the phenothiazine group. ... Categories: Stub | Typical antipsychotics ... This article needs to be cleaned up to conform to a higher standard of quality. ... Prochlorperazine is a highly potent neuroleptic, which is 10 to 20-times more potent than chlorpromazine. ... Pimozide (Orap®) is an antipsychotic drug. ...

See also

• atypical antipsychotic

The atypical antipsychotics (also known as second generation antipsychotics) are a class of prescription medications used to treat psychiatric conditions. ...