United States Highway 50 is an east-west United States highway. As the "0" in its route number suggests, US 50 is a coast-to-coast route, or at least nearly so. Signs at both termini give the Maryland to California distance as 3073 miles, though the exact mileage will surely vary due to bypasses, Interstate highway co-signings, and other realignments.

US 50 serves both Jefferson City, Missouri, and Carson City, Nevada, two of only five state capitals not served by an Interstate highway.

In Nevada, the US 50 is, without too much hyperbole, known as "The Loneliest Road in America".

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	U.S. fifty-dollar bill - Wikipedia, the free encyclopedia (1140 words) U.S. President Ulysses S. Grant is currently featured on the obverse, while the U.S. Capitol is featured on the reverse. 1869: A new $50 United States Note was issued with a portrait of Henry Clay on the right and an allegorical figure holding a laurel branch on the left of the obverse. All variations of the $50 bill would carry the same portrait of Ulysses S. Grant, same border design on the obverse, and the same reverse with a vignette of the U.S. Capital. U.S. Highway 50 - Wikipedia, the free encyclopedia (656 words) US 50 once extended all the way to San Francisco, by going south through Stockton and then west to the San Francisco-Oakland Bay Bridge. US 50 is part of the Appalachian Development Highway System's Corridor D from Clarksburg, West Virginia to Parkersburg, West Virginia at the Ohio River US 50 is part of the Appalachian Development Highway System's Corridor D from Parkersburg, West Virginia at the Ohio River to Cincinnati, Ohio
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