US 425 is an north-south United States highway. Its route number is a "violation" of the usual AASHTO numbering scheme, as it comes nowhere near its implied "parent", US 25.
UnitedStatesHighway 35 is an north-south UnitedStateshighway that runs northwest-southeast for 424 miles (682 km) from northern Indiana to the western suburbs of Charleston, West Virginia.
Interstate 64 is an interstate highway in the eastern UnitedStates.
UnitedStatesHighway 33 is a north-south UnitedStateshighway that runs northwest-southeast for 709 miles (1,141 km) from northern Indiana to Richmond, Virginia.