Uptown in Manhattan, New York City, refers to the northern part of Manhattan : generally speaking, North of 59th Street. In Manhattan, particularly when one is in roughly the southern half of the borough, it can also mean "north" or "northbound," as in "I'm going uptown." The Borough of Manhattan, highlighted in yellow, lies between the East River and the Hudson River. ... Nickname: The Big Apple, The Capital of the World Official website: City of New York Government Counties (Boroughs) Bronx (The Bronx) New York (Manhattan) Queens (Queens) Kings (Brooklyn) Richmond (Staten Island) Mayor Michael Bloomberg (R) Geographical characteristics Area Total 468. ...