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Encyclopedia > Valproate semisodium

Valproate semisodium (INN) or divalproex sodium (USAN) consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. It is used in the UK and U.S. for the treatment of the manic episodes of bipolar disorder, and increasingly taken long-term for prevention of both manic and depressive phases of bipolar disorder, especially the rapid-cycling variant. It is also used in the US for the treatment of epilepsy, chronic pain associated with neuropathy, and migraine headaches. Its chemical name is sodium hydrogen bis(2-propylpentanoate). The extended release formulation allows for a single daily dose. An International Nonproprietary Name (INN) is the official non-proprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization. ... There have been a number of attempts to coin an alternative to American as an adjective (a demonym) for United States nationals. ... Sodium valproate (INN) or valproate sodium (USAN) is the sodium salt of valproic acid and is an anticonvulsant used in the treatment of epilepsy. ... Valproic acid is a chemical compound that has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy and bipolar disorder. ... Enteric means pertaining to the intestine. ... Motto: (Out Of Many, One) (traditional) In God We Trust (1956 to date) Anthem: The Star-Spangled Banner Capital Washington D.C. Largest city New York City None at federal level (English de facto) Government Federal constitutional republic  - President George Walker Bush (R)  - Vice President Dick Cheney (R) Independence from... Mania is a severe medical condition characterized by extremely elevated mood, energy, and thought patterns. ... For other uses, see Bipolar. ... It is common to feel sad, discouraged , or down once in a while, and anyone in this state might say they are suffering from depression. ... Chronic pain was originally defined as pain that has lasted 6 months or longer. ... Neuropathy is usually short for peripheral neuropathy, meaning a disease of the peripheral nervous system. ... Migraine is a form of headache, usually very intense and disabling. ...


In the UK semisodium valproate has been sold for a few years as the proprietary drug Depakote and marketed for psychiatric conditions only. It is about five times the price of sodium valproate, which has been marketed for around 30 years as Epilim by the same company for epilepsy and is also available from other manufacturers as a generic product.


Side effects

People who take this drug can experience a variety of side effects, some of which may or may not require immediate medical attention. Especially dangerous side effects include vomiting, loss of appetite, fever, or dark urine. These suggest a possibility of liver damage. People taking this drug should also call their doctor if they experience other serious side effects. Some serious side effects are unusual bleeding (especially in the urine), hallucinations, and extreme drowsiness. An adverse drug reaction (abbreviated ADR) is a term to describe the unwanted, negative consequences sometimes associated with the use of medications. ... A hallucination is a sensory perception experienced in the absence of an external stimulus, as distinct from an illusion, which is a misperception of an external stimulus. ...


Branded formulations

The patent held by Abbott Laboratories will expire on January 29, 2008.[citation needed] Abbott Laboratories (NYSE: ABT) is a diversified pharmaceuticals and health care company. ... Abbott Laboratories (NYSE: ABT) is a diversified pharmaceuticals and health care company. ... Sanofi-aventis (Euronext: SAN, NYSE: SNY), headquartered in Paris, France, is one of the 3 largest pharmaceutical companies in the world, along with Pfizer,GlaxoSmithKline. ... Abbott Laboratories (NYSE: ABT) is a diversified pharmaceuticals and health care company. ... Abbott Laboratories (NYSE: ABT) is a diversified pharmaceuticals and health care company. ... January 29 is the 29th day of the year in the Gregorian calendar. ... 2008 (MMVIII) will be a leap year starting on Tuesday of the Gregorian calendar. ...


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