In these, Vecchietta's Florentine formation is evident combined with his elegantly linear style and with certain significant novelties where, for example, are to be compared the figures of Adam and Eve which Masolino da Panicale - with whom Vecchietta had collaborated - frescoed in the Brancacci Chapel in symmetry with Masaccio's stupendously dramatic nudes.
In point of fact, unlike the kindly impassiveness of the two progenitors painted by Masolino, those of the Vecchietta are painted genuflecting in the Garden of Eden in the act of thanking the Lord.
Vecchietta painted other works for the hospital and made masterpieces in bronze including, in 1472, the great ciborium which Pandolfo Petrucci, that enlightened tyrant of Siena, had transferred in 1506 to the high altar in the Cathedral.
A series of frescoes in the Baptistery of S. Giovanni were executed with the assistance of pupils, but much is identified as Vecchietta's own; the Evangelists, the Four Articles of the Creed, the Assumption, containing some lovely angels' heads, and symbolical figures of Virtues.
In the Galleria di belle Arti are a Madonna and some minor works; a St. Martin in the Palazzo Saracini; two panels in the Palazzo Publico, a sermon and miracle of St. Bernardino (sometime attributed to di Giorgio), and a beautiful Our Lady of Pity.
Outside Siena the artist's chief painting, an Assumption, of (1451), is in the church at Pienza; in Florence a Madonna panel and the bronze tomb statute of Marianus Soccinus the Elder (removed from S. Domenico, Siena), a noted Sienese jurisconsult, are in the Uffizi.