Virius Lupus was a Roman soldier and politician of the late second and early third century AD.

He served as a legate of one of the German provinces and supported Septimus Severus during the civil war that followed the murder of Pertinax. In 196 his troops were defeated by Decimus Clodius Albinus as the fight for the throne intensified.

He would have served as consul some time previously and became governor of Roman Britain once Severus was made emperor in 197.

Severus sent him to Britain immediately to recover the province from the rebellions that had swept it following Clodius Albinus' removal of most of the garrison to press his claim for the throne the previous year.

In the north he was obliged to buy peace from the Maeatae. Fearful that they would ally with the Caledonian Confederacy and unable to secure troop reinforcements from Severus, Lupus had no choice but to pay the rebels in return for their withdrawal and the return of a few prisoners. Lupus slowly restored the forts in the Pennines to Roman control although Hadrian's Wall was not rebuilt until c. 205.

His governorship was assisted by the arrival of Sextus Varius Marcellus as provincial procurator and in who can be seen the germ of the later division of Britain into two provinces.

He served as governor until 201 or 202.