Weird Science was part of the EC Comics line in the early 1950s. The bi-monthly science-fiction comic, published by Bill Gaines and edited by Al Feldstein, began with an issue cover-dated May-June, 1950. Over a three-year span, it ran for 22 issues, ending with the November-December, 1953 issue. Entertaining Comics was headed by William Gaines but is better known by its publishing name of EC Comics. ... William Maxwell Gaines (March 1, 1922–June 3, 1992), or Bill Gaines as he was called, was the founder of MAD Magazine but he was also noted for his efforts to create comic books of sufficient artistic quality and interest to appeal to adults. ... Al Feldstein was the editor of EC Comics line of horror, science-fiction, and suspenstories titles in the 1950s. ...

Early cover illustrations were by Feldstein; Wally Wood took over as the regular cover illustrator in 1952. Artists who drew stories for this EC title were Feldstein, Wood, Frank Frazetta, Al Williamson, Joe Orlando, George Evans, Harvey Kurtzman, George Roussos, Harry Harrison, Will Elder, Jack Kamen, Sid Check and Jack Olesen. Wallace Wally Wood (June 17, 1927–November 2, 1981), best known for his work in EC Comics and Mad magazine, was an imaginative writer-illustrator who freelanced to a wide variety of markets. ... Joe Orlando was an illustrator and cartoonist who was born April 4, 1927, in Bari, Italy, and died December 23, 1998, in Manhattan. ... William Elder (born 1921) is a comic book artist. ...

The companion comic for Weird Science was Weird Fantasy. The two titles merged in 1955 to become Weird Science-Fantasy, which ran for seven issues before a title change to Incredible Science Fiction for four issues.