His sister Susannah Fowler married Sir John Drummond, and was mother of the poetWilliam Drummond of Hawthornden.
On the title-page of The Triumphs of Petrarke, Fowler styles himself "P. of Hawick," which has been held to mean that he was parson of Hawick, but this is doubtful.
Fowler contributed a prefatory sonnet to James VI.'s Furies; and James, in return, commended, in verse, Fowler's Triumphs.
William A. Fowler was born on 9 August 1911, in Pittsburgh, Pennsylvania, to John MacLeod, an accountant, and Jennie Summers (Watson) Fowler.
Fowler was married to the former Ardiane Foy Olmsted on August 24, 1940.
Fowler received the 1983 Nobel Prize in physics in recognition of "his theoretical and experimental studies of the nuclear reactions of important atoms in the formation of the chemical elements in the universe." His contributions have been of benefit to the fields of astronomy, astrophysics, cosmology, and geophysics in addition to nuclear physics.