Wilmslow Road is a major thoroughfare in South Manchester running from Parrs Wood to Manchester City Centre. Its name changes to Oxford Road in Rusholme and as it passes the University of Manchester, and changes again, to Oxford Street, when it reaches the city centre proper.

It runs through the centres of East Didsbury, Withington and Fallowfield.

It is most notable as the busiest bus route in Europe, with at least five companies operating many routes. This is partly because it is the main route for students travelling between the residential area of Fallowfield, where many halls of residence are situated (among them Owens Park), and the main campuses of the University of Manchester and Manchester Metropolitan University. Magicbus, Stagecoach and R. Bullocks are among the competing bus companies.