Beginning of the "Little Ice Age" a cooling period that resulted in lower crop yields across the world, and harsher climates especially in northern latitudes.
First circumnavigation of the globe by a ship of Ferdinand Magellan's expedition. Only one ship survived the journey, under the command of the Basque captain Juan Sebastián Elcano (1522).
In the Diet of Speyer, a group of princes and imperial cities of the Holy Roman Empire sign a protestation against the Edict of Worms. This marks their support of Lutheranism (1529).