Yohimbine
Chemical name	17α-hydroxy-yohimban-16α- carboxylic acid methyl ester
Chemical formula	C21H26N2O3
Molecular mass	354.44 g/mol (base) 390.90 g/mol (hydrochloride)
CAS number	146-48-5
SMILES	[H][C@@]3(N(CC4)C[C@@]5([H])[C@] ([C@@H]([C@@](OC)=O)[C@@H](O)CC5) ([H])C3)C2=C4C1=C(N2)C=CC=C1

Yohimbine, also known under the outdated names quebrachin, aphrodin, corynine, yohimvetol, and hydroergotocin, is the principal alkaloid of the bark of the West-African tree Pausinystalia yohimbe Pierre (formerly Corynanthe yohimbe), family Rubiaceae (Madder family). There are 31 other yohimbane alkaloids found in Yohimbe. IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The simplified molecular input line entry specification or SMILES is a specification for unambiguously describing the structure of chemical molecules using short ASCII alpha-numeric strings. ...

Pharmacology

Yohimbine is a selective competitive alpha2-adrenergic receptor antagonist and is used for treating erectile dysfunction. It is claimed to be an aphrodisiac. It is also used as a weight loss supplement as it increases Norepinephrine (noradrenaline) levels. Competition characterises a biochemical, ecologic, economic, political, or sporting activity whereby two or more individuals or groups strive antagonistically against one another for some reward. ... The adrenergic receptors (or adrenoceptors) are a class of G_protein coupled receptors that is the target of catecholamines. ... Receptor may refer to: In telecommunication, a receiver. ... Categories: Biology stubs | Biochemistry | Pharmacology ... Impotence or, more clinically, erectile dysfunction is the inability to maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. ... In the context of physical health, weight loss is the process of losing body weight, usually by losing fat. ... Norepinephrine, known as noradrenaline outside the USA, is a catecholamine and a phenethylamine with chemical formula C8H11NO3. ...

Higher doses of oral Yohimbine create numerous side effects such as rapid heart rate, high blood pressure, and overstimulation. Yohimbine is also used clinically to produce anxiety.

Some internet shops even sell expensive formulations of Yohimbine for percutaneous delivery to effect a local reduction of adipose tissue. From a pharmaceutical standpoint this seems highly unlikely and no evidence whatsoever is presented. In surgery, percutaneous pertains to any medical procedure where access to inner organs or other tissue is done via needle-puncture of the skin, rather than by using an open approach where inner organs or tissue are exposed (typically with the use of a scalpel). ... Pharmacy (from the Greek φάρμακον = drug) is the profession of compounding and dispensing medication. ...

External links

• Chemical data (German) (http://www.omikron-online.de/cyberchem/cheminfo/yohimbin.htm).
• German article (http://www.pharmazeutische-zeitung.de/pza/1999-47/titel.htm) (a good review).
• Pausinystalia yohimbe (http://www.bottlebrushpress.com/yohimbe.html)
• Pausinystalia yohimbe (http://www.geocities.com/nutriflip/Naturopathy/Yohimbe.html)