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Encyclopedia > Zinc finger inhibitor

Zinc finger inhibition is the process by which the synthesis of zinc fingers is blocked. Zinc finger inhibitors have been tested for their efficacy in treating AIDS and HIV. AIDS (Acquired Immunodeficiency Syndrome or Acquired Immune Deficiency Syndrome, sometimes written Aids) is a global, human epidemic. ... HIV (Human Immunodeficiency Virus) is a retrovirus that infects cells of the human immune system. ...


  Results from FactBites:
 
Zinc finger - Wikipedia, the free encyclopedia (302 words)
A zinc finger consists of two antiparallel β strands, and an α helix.
The structure of each individual finger is highly conserved and consists of about 30 amino acid residues, constructed as a ββα fold and held together by the zinc ion.
These proteins typically interact with the major groove along the double helix of DNA in which case the zinc fingers are arranged around the DNA strand in such a way that the α-helix of each finger contacts the DNA, forming an almost continuous stretch of α-helices around the DNA molecule.
The Body: Anti-HIV Drugs in Early Development (1925 words)
Unlike reverse transcriptase inhibitors and protease inhibitors which interfere with viral reproduction once HIV is inside the cell, pentafuside prevents HIV from successfully docking with T-cells, protecting the cell from infection.
Zinc fingers are part of the protein responsible for protecting and repackaging HIV-RNA on its way in and out of a cell's nucleus.
Zintevir is an inhibitor of integrase, the third of three retroviral enzymes long considered by researchers to be an ideal therapeutic target (the other two are reverse transcriptase and protease).
  More results at FactBites »


 

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