Alitame is an artifical sweetener developed by Pfizer in the early 1980s and currently marketed in some countries under the brand name Aclame. Like aspartame, alitame is an aspartic acid-containing dipeptide. Most dipeptides are not sweet, but the unexpected discovery of aspartame in 1965 led to a search for similar compounds that shared its sweetness. Alitame is one such second-generation dipeptide sweetener. Neotame, developed by the owners of the NutraSweet brand, is another. A sweetener is a food additive which adds the basic taste of sweetness to a food. ... Pfizer, Incorporated (NYSE: PFE), is a global pharmaceutical company, with headquarters in New York City. ... Aspartame is the name for the artificial, non_carbohydrate sweetener, Aspartyl-phenylalanine-1-methyl ester; i. ... Aspartic acid, also known as aspartate, the name of its anion, is one of the 20 natural proteinogenic amino acids which are the building blocks of proteins. ... A dipeptide is a molecule consisting of two amino acids joined by a single peptide bond. ... 1965 was a common year starting on Friday (the link is to a full 1965 calendar). ... Neotame is an artificial sweetener derived from and similar in structure to aspartame. ...

Alitame has several distinct advantages over aspartame. It is about 2000 times sweeter than sucrose, about 10 times sweeter than aspartame, and has no aftertaste. Its half-life under hot or acidic conditions is about twice as long as aspartame's, although some other artificial sweeteners, including saccharin and acesulfame, are more stable yet. Unlike aspartame, alitame does not contain phenylalanine, and can therefore be used by people with phenylketonuria. This article needs cleanup. ... Half-Life For a quantity subject to exponential decay, the half-life is the time required for the quantity to fall to half of its initial value. ... Saccharin is the oldest artificial sweetener; it was discovered in 1879 by Ira Remsen and Constantine Fahlberg of Johns Hopkins University. ... Acesulfame potassium is a calorie-free artificial sweetener, also known as Acesulfame K or Ace K, which was discovered in 1967 by Hoechst AG. Acesulfame potassium is the potassium salt of 6-methyl-1,2,3- oxathiazine-4(3H)-one-2,2-dioxide. ... The amino acid Phenylalanine exists in two forms, the D- and L- forms. ... Phenylketonuria fee-nil-kee-ton-yur-ee-aah+ (PKU) is a human genetic disorder that occurs in about 1 in 15,000 births, but the incidence varies widely in different human populations from 1 in 4,500 births among the Irish to fewer than one in 100,000 births among...

Alitame has approved for use in Mexico, Australia, New Zealand and China. Pfizer petitioned the Food and Drug Administration to permit alitame's use in the United States in 1986, but as of 2005, this petition is still pending. The United Mexican States or Mexico (Spanish: Estados Unidos Mexicanos or México; regarding the use of the variant spelling Méjico, see section The name below) is a country located in North America, bordered to the north by the United States of America, to the southeast by Guatemala and Belize, to... Australia, officially the Commonwealth of Australia, is the sixth-largest country in the world, the only country to occupy an entire continent, and the largest in the region of Australasia/Oceania. ... New Zealand is an independent sovereign state in the south-western Pacific Ocean. ... The Great Wall of China, stretching over 6,700 km, was erected beginning in the 3rd century BC to guard the north from raids by men on horses. ... The United States Food and Drug Administration (FDA) is the government agency responsible for regulating food (human and animal), dietary supplements, drugs (human and animal), cosmetics, medical devices (human and animal), biologics and blood products in the United States. ... The United States of America — also referred to as the United States, the U.S.A., the U.S., America, the States, or (archaically) Columbia—is a federal republic of 50 states located primarily in central North America (with the exception of two states: Alaska and Hawaii). ... 1986 is a common year starting on Wednesday of the Gregorian calendar. ... 2005 is a common year starting on Saturday of the Gregorian calendar. ...

References

Ellis, J.W. 1995. Overview of sweeteners. J. Chem. Educ. 72: pp. 671-675.