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United States Patent Application: 0040091546 (15321 words) |
 | Amphiphilic copolymers and the additive target molecules can be mixed in a ratio between about 1:20 to about 20:1 by weight and result in nanoparticles of amphiphilic copolymers with additive target molecule. |
| The amphiphilic copolymers used in this invention are comprised of blocks of at least two sub-units or with a minimum contour length the equivalent of at least 5 ethylene units and of a given character and a molecular weight of at least 300 g/mole. |
| In the present case, nanoparticle compositions in which amphiphilic copolymers contain PEO as the water soluble component are used for steric stabilization of a target molecule are desirable to obtain the properties for a pharmaceutical formulation. |
| Patent 6,814,971 (3671 words) |
| The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal. |
| In another preferred embodiment, two amphiphilic surfactants are used in an adjuvant of the invention, for example a Tween and a Span surfactant. |
| Amphiphilic surfactants useful in the adjuvant of the invention have HLB values from about 2 to about 20, preferably from about 3 to about 17. |
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