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We next hear of Acacius in Rome, apparently as a deputy on the part of Meletius and the Fathers of the Antiochene Synod, when the questions connected with the heresy of Apollinaris came up for discussion before Pope Damasus.
Indeed, he was one of the notorious "four" whom the Saint particularly named as men at whose hands he could not expect to obtain common justice.
In every one of the various synods convened for the Saint's undoing, the restless old man of Beroea took a leading and almost acrimonious part, and even made a laborious, but happily futile, effort to win over Pope Innocent to his uncharitable view.