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Autologous Chondrocyte Implantation (2607 words) |
 | Ideally, candidates for autologous chondrocyte implant should be between 15 and 45 years of age, have full thickness localized defects of the femoral condyles, have intact menisci, have no generalized chondromalacia, have no limb misalignment and are willing and able to undergo vigorous rehabilitation. |
| The TEC assessment noted that three of the four components of autologous chondrocyte implantation -- use of a periosteal flap, debridement and rehabilitation – are not unique to autologous chondrocyte implantation, and these components of the procedure may account for some or all of the clinical improvements noted in uncontrolled studies of this procedure. |
| The assessment noted that most of the available evidence for autologous chondrocyte implant is from uncontrolled case series, and that this literature is subject to bias because of the inherent weakness of case series. |
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Autologous Chondrocyte Implantation (ACI): (731 words) |
| Meniscal cartilage is on the tibia and serves mostly as a shock absorber. |
| Autologous Chondrocyte Implantation is used to repair defects to the articular cartilage. |
| However, when the cartilage is damaged, the chondrocytes' distance from a blood supply means that they lack the ability to regenerate themselves, a process that requires an increased amount of nutrients and access through the blood stream to other cells and proteins that stimulate the regeneration. |
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