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Encyclopedia > Cortisone
Cortisone
Chemical structure of cortisone
Systematic name 17-hydroxy-11-dehydrocorticosterone
Chemical formula C21H28O5
Molecular mass 360.46 g/mol
Density  ? g/cm3
Melting point 220-224 °C
CAS number [53-06-5]
SMILES C[C@@](C3)4[C@](CC[C@@](O)4
[C@@](CO)=O)([H])[C@]2([H])CCC1=CC
(CC[C@@](C)1[C@]([H])2C3=O)=O
Disclaimer and references

Cortisone (IPA:ˈkôrtəˌsōn) is a steroid hormone. Chemically, it is a corticosteroid with formula C21H28O5 and IUPAC name 17-hydroxy-11-dehydrocorticosterone. It is closely related to corticosterone. Image File history File links Download high resolution version (930x638, 13 KB) Summary Chemical structure of cortisone created with ChemDraw. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass (abbreviated MM) of a substance, called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... Density (symbol: ρ - Greek: rho) is a measure of mass per unit of volume. ... The melting point of a solid is the temperature at which it changes state from solid to liquid. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The simplified molecular input line entry specification or SMILES is a specification for unambiguously describing the structure of chemical molecules using short ASCII strings. ... Steroid skeleton. ... A hormone (from Greek horman - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ... In physiology, corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. ... There are millions of possible objects that can be described in science, too many to create common names for every one. ... Corticosterone is a 21 carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. ...


Cortisone and adrenaline are the main hormones released by the body as a reaction to stress. They elevate blood pressure and prepare the body for a fight or flight response. Epinephrine (INN) or adrenaline (BAN) is a hormone and a neurotransmitter. ... This article or section should include material from Fight-or-flight The flight or fight response, also called the acute stress response, was first described by Walter Cannon in the 1920s as a theory that animals react to threats with a general discharge of the sympathetic nervous system. ...


Cortisone is the inactive precursor molecule of the active hormone cortisol. It is activated through hydroxylation of the 11-keto-group by an enzyme called 11-beta-steroid dehydrogenase. The active form cortisol is thus sometimes referred to as hydrocortisone. Cortisol is a corticosteroid hormone that is involved in the response to stress; it increases blood pressure and blood sugar levels and suppresses the immune system. ... Hydroxylation is any chemical process that introduces one or more hydroxyl groups (-OH) into a compound (or radical) thereby oxidising it. ... Ribbon diagram of the enzyme TIM. TIM is catalytically perfect, meaning its conversion rate is limited, or nearly limited to its substrate diffusion rate. ... Hydrocortisone is a synthetic corticosteroid drug which may be given by injection or by topical application. ...


Cortisone is sometimes used as a drug to treat a variety of ailments. It can be administered intravenously or cutaneously. An intravenous drip in a hospital Intravenous therapy or IV therapy is the administration of liquid substances directly into a vein. ... This article is about skin in the biological sense. ...


One of cortisone's effects on the body, and a potentially harmful side effect when administered clinically, is the suppression of the immune system. This is an explanation for the apparent correlation between high stress and sickness. In the medical world, stress is defined as one of the following: An applied force or system of forces that tends to strain or deform a body, The resisting force set up in a body as a result of an externally applied force, or A physical or psychological stimulus that...


Cortisone is less important than a similar steroid cortisol. Cortisol is responsible for 95% of the effects of the gluccocorticosteroids while cortisone is about 4 or 5%. Corticosterone is even less important. Cortisol is a corticosteroid hormone that is involved in the response to stress; it increases blood pressure and blood sugar levels and suppresses the immune system. ... Corticosterone is a 21 carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. ...


Cortisone was first discovered by the American chemist Edward Calvin Kendall. He won the 1950 Nobel Prize for Physiology or Medicine along with Philip S. Hench and Tadeus Reichstein for the discovery of adrenal cortex hormones, their structures, and functions. Edward Calvin Kendall (March 8, 1886 - May 4, 1972) was an American chemist who, with Philip S. Hench and Tadeus Reichstein, won the Nobel Prize for Physiology or Medicine in 1950 for research on the structure and biological effects of adrenal cortex hormones. ... List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ... Philip Showalter Hench (February 28, 1896 - March 30, 1965) was an American physician who, with E. C. Kendall, in 1948 successfully applied an adrenal hormone (later known as cortisone) in the treatment of rheumatoid arthritis. ... Tadeus Reichstein (July 20, 1897 - August 1, 1996) was a Polish Nobel Prize-winning chemist. ... In mammals, the adrenal glands are the triangle-shaped endocrine glands that sit atop the kidneys. ...


Reference

  • Merck Index, 11th Edition, 2533

See also

Central serous retinopathy or CSR is a visual impairment, often temporary, usually in one eye, affecting males in the age group 20 to 50. ... Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. ...

External links


Corticosteroids - glucocorticoid/receptor and mineralocorticoid/receptor edit
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B)

Alclometasone, Aldosterone, Amcinonide, Beclometasone, Betamethasone, Budesonide, Ciclesonide, Clobetasol, Clobetasone, Clocortolone, Cloprednol, Cortisone, Cortivazol, Deflazacort, Deoxycorticosterone, Desonide, Desoximetasone, Desoxycortone, Dexamethasone, Diflorasone, Diflucortolone, Difluprednate, Fluclorolone, Fludrocortisone, Fludroxycortide, Flumetasone, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortin, Fluocortolone, Fluorometholone, Fluperolone, Fluprednidene, Fluticasone, Formocortal, Halcinonide, Halometasone, Hydrocortisone/cortisol, Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate, Loteprednol, Medrysone, Meprednisone, Methylprednisolone, Methylprednisolone aceponate, Mometasone furoate, Paramethasone, Prednicarbate, Prednisone/Prednisolone, Prednylidene, Rimexolone, Tixocortol, Triamcinolone, Ulobetasol In physiology, corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. ... Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger similar effects. ... The ‘’’glucocorticoid receptor’’’ (GR) is a ligand-activated intracytoplasmatic transcription factor that interacts with high affinity to cortisol and other glucocorticoids. ... Mineralocorticoids is a class of steroids characterised by their similarity to aldosterone and their influence on salt and water metabolism. ... The mineralocorticoid receptor (MR, MLR, MCR), also aldosterone receptor, is officially labelled nuclear receptor subfamily 3, group C, member 2, (NR3C2) and is a receptor with high affinity for mineralocorticoids. ... A division of the Anatomical Therapeutic Chemical Classification System A Alimentary tract and metabolism A07A Intestinal anti-infectives A07AA Antibiotics A07AA01 Neomycin A07AA02 Nystatin A07AA03 Natamycin A07AA04 Streptomycin A07AA05 Polymyxin B A07AA06 Paromomycin A07AA07 Amphotericin B A07AA08 Kanamycin A07AA09 Vancomycin A07AA10 Colistin A07AA11 Rifaximin A07AA51 Neomycin, combinations A07AA54 Streptomycin, combinations... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Alclometasone is a synthetic glucocorticoid steroid, available in cream or ointment form, for topical dermatologic use. ... Aldosterone is a steroid hormone synthesized from cholesterol by the enzyme aldosterone synthase. ... Amcinonide is a corticosteroid. ... Beclometasone dipropionate (INN, Beclomethasone dipropionate (BAN) is a corticosteroid drug. ... Betamethasone dipropionate is a corticosteroid with anti-inflammatory and immunosuppressive abilities, used especially where water retention is undesirable. ... Budesonide is a corticosteroid for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. ... Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. ... Clobetasol Propionate comes in ointment and emollient cream presentations. ... Clobetasone is a corticosteroid used in dermatology and ophthalmology. ... Clocortolone (or clocortolone pivalate) is a corticosteroid. ... Cloprednol is a glucocorticoid. ... Cortivazol is a glucocorticoid. ... Deflazacort is a glucocorticoid. ... Deoxycorticosterone Deoxycorticosterone is a steroid hormone produced by the adrenal gland that posses mineralocorticoid activity and acts as a precursor to aldosterone. ... Desonide is an anti-inflammatory corticosteroid typically used topically. ... Brand name is : Topicort Pronounced: TOP-i-court Generic name: Desoximetasone This medication belongs to the family of medications known as topical corticosteroids. ... Desoxycorticosterone (11-deoxycorticosterone) is a mineralocorticoid. ... Dexamethasone is a synthetic member of the glucocorticoid class of hormones. ... Diflorasone is a corticosteroid. ... Diflucortolone is a corticosteroid. ... Difluprednate is a corticosteroid. ... Fluclorolone is a corticosteroid. ... Fludrocortisone acetate is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. ... Floudroxycortide (or Flurandrenolone or Flurandrenolide ) is a synthetic steriod and is used as an anti-inflammatory treatment for use on skin irritations. ... Flumethasone (or flumetasone) is a corticosteroid. ... Flunisolide is a corticosteroid often prescribed as treatment for allergic rhinitis. ... Fluocinolone acetonide is a corticosteroid primarily used in dermatology. ... To meet Wikipedias quality standards, this article or section may require cleanup. ... Fluocortin is a corticosteroid. ... Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. ... Fluorometholone is a corticosteroid, most often used after Laser Eye Surgery. ... Fluperolone acetate is a corticosteroid. ... Fluprednidene acetate is a corticosteroid. ... Fluticasone proprionate is a glucocorticoid often prescribed as treatment for asthma and allergic rhinitis. ... Formocortal is a corticosteroid used in ophthalmology. ... Halcinonide is a corticosteroid. ... Halometasone is a corticosteroid. ... Cortisol is a corticosteroid hormone that is involved in the response to stress; it increases blood pressure and blood sugar levels and suppresses the immune system. ... Hydrocortisone aceponate is a corticosteroid. ... Hydrocortisone buteprate (or hydrocortisone 17-butyrate 21-propionate) is a corticosteroid. ... Steroid skeleton. ... Loteprednol (or loteprednol etabonate) is a corticosteroid used in ophthalmology. ... Medrysone is a corticosteroid used in ophthalmology. ... Meprednisone is a glucocorticoid. ... Methylprednisolone (molecular weight 374. ... Methylprednisolone aceponate is a corticosteroid. ... Mometasone furoate (also referred to as Mometasone) is a moderately potent glucocorticoid steroid used in the treatment of inflammatory skin disorders (such as eczema and psoriasis) and allergic rhinitis (such as hayfever) unresponsive to less potent corticosteroids. ... Paramethasone is a fluorinated glucocorticoid used as an anti-inflammatory. ... Prednicarbate is a corticosteroid. ... Prednisone is a synthetic corticosteroid drug which is usually taken orally and can be used for a large number of different conditions. ... Prednylidene is a glucocorticoid for systemic use. ... Rimexolone (Vexol®) is a corticosteroid, often used in eye drops to treat inflammation in the eye. ... Tixocortol is a corticosteroid used as a intestinal anti-inflammatory and decongestant. ... This article needs to be cleaned up to conform to a higher standard of quality. ... Ulobetasol (or halobetasol) is a corticosteroid. ...


  Results from FactBites:
 
The Truth About Cortisone Shots (1286 words)
Cortisone by itself is rarely used today as it is relatively short acting and of low potency.
Cortisone is useful in suppressing inflammation in the short term, and in the long term, dissolving scar tissue, stabilizing the body's defenses, speeding the healing process, and is very effective in causing certain cysts to disappear.
There is a limit to the amount of cortisone given in one dose, even if injected in several areas of the body; this varies depending on the size and physical condition of the person.
Wonder drug: cortisone (390 words)
Cortisone is a type of steroid produced naturally by your adrenal gland and released when your body is stressed.
Probably the most common is a “cortisone flare,” a condition where the injected cortisone crystallizes and can cause a period of pain worse than before the shot.
Beware: prolonged use of cortisone, especially when ingested orally, can have side effects ranging from inconsequential to horrific and must be carefully monitored by a physician specializing in internal medicine.
  More results at FactBites »


 

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