Dopaminergic means "related to the neurotransmitter dopamine". A synapse is dopaminergic if it uses dopamine as its neurotransmitter. A substance is dopaminergic if it is capable of producing, altering, or releasing dopamine. Chemical structure of D-aspartic acid, a common amino acid neurotransmitter. ... Dopamine is a phenethylamine naturally produced by the human body. ... Illustration of the major elements in a prototypical synapse. ... Dopamine is a phenethylamine naturally produced by the human body. ...

A dopaminergic, or dopaminergic agent, is any chemical which functions to enhance the effects mediated by dopamine in the central nervous system. These include dopamine precursors and cofactors, dopaminergic enzymes, as well as dopamine reuptake inhibitors. A chemical substance is any material substance used in or obtained by a process in chemistry: A chemical compound is a substance consisting of two or more chemical elements that are chemically combined in fixed proportions. ... A diagram showing the CNS: 1. ... A cofactor is the following: In mathematics a cofactor is the minor of an element of a square matrix. ... Ribbon diagram of the enzyme TIM, surrounded by the space-filling model of the protein. ... This does not cite any references or sources. ...

Dopaminergics

Dopaminergics are substances that affect the neurotransmitter dopamine or the components of the nervous system that use dopamine. Dopamine is produced in the synthesis of all catecholamine neurotransmitters, and is the rate limiting step for this synthesis. Dopaminergic nootropics include dopamine precursors and cofactors, and dopamine reuptake inhibitors: Dopamine is a phenethylamine naturally produced by the human body. ... tyrosine is the precursor of catecholamines epinephrine norepinephrine dopamine Synthesis Catecholamines are chemical compounds derived from the amino acid tyrosine containing catechol and amine groups. ... Dopamine reuptake inhibitors are compounds that increase amounts of the neurotransmitter dopamine in the brain by inhibiting its reuptake at synapses. ...

• L-dopa - Prescription drug. Precursor to the neurotransmitter dopamine, anti-depressant.
• Phenylalanine (requires Vitamin B6 and Vitamin C) - Essential amino acid. Precursor to dopamine, anti-depressant, sleep reducer.
• Theanine - Found in tea. Increases serotonin, GABA and dopamine levels in the brain. Increases alpha-wave based alert relaxation.
• Tyrosine (requires Vitamin B6 and Vitamin C) - Amino acid. Precursor to dopamine, anti-depressant, sleep reducer.
• Vitamin C- improves cardiovascular elasticity and integrity, membrane stabilizer and major anti-oxidant (protects brain cells and prevents brain cell death), cofactor in the production of the neurotransmitters dopamine and serotonin.
• Vitamin B6 - co-factor used by the body to produce dopamine.
• Yohimbe - Bark. Boosts dopamine levels as much as 80%^{[citation needed]}, though how it does this is not yet understood. Aphrodisiac. Yohimbe poses some health risks through its side-effects: it is a neuro-paralytic which slows down breathing and induces acidosis, some symptoms of which are malaise, nausea, and vomiting. Contraindicated for users of megadoses of acidic vitamins or nutrients.
• Selegiline Inhibits MAO-B (an enzyme that breaks down dopamine) thus raising dopamine by partially inhibiting its breakdown. (In large doses it also inhibits MAO-A)
• Tolcapone - Inhibits COMT (an enzyme that breaks down the neurotransmitters dopamine, epinephrine, and norepinephrine) and increases performance in tasks depending on working memory in individuals with the val/val and val/met genotype of the val158Met polymorphism of the catechol-O-methyltransferase gene, while decreasing it in presence of the met/met version. Tolcapone presents the risk of deadly side effects.

// Therapeutic use L-DOPA is used to replace dopamine lost in Parkinsons disease because dopamine itself cannot cross the blood-brain barrierwhere its precursor can. ... Phenyl alanine is an α-amino acid with the formula HO2CCH(NH2)CH2C6H5. ... Pyridoxine Pyridoxal phosphate Vitamin B6 is a water-soluble vitamin. ... For other uses, see Vitamin C (disambiguation). ... An essential amino acid or indispensable amino acid, is an amino acid that cannot be synthesized de novo by the organism (usually referring to humans), and therefore must be supplied in the diet. ... Theanine is an amino acid which is a deriviative of glutamine. ... Gaba may refer to: Gabâ or gabaa (Philippines), the concept of negative karma of the Cebuano people GABA, the gamma-amino-butyric acid neurotransmitter GABA receptor, in biology, receptors with GABA as their endogenous ligand Gaba 1 to 1, an English conversational school in Japan Marianne Gaba, a US model... Tyrosine (from the Greek tyros, meaning cheese, as it was first discovered in 1846 by German chemist Justus von Liebig in cheese[1][2]), 4-hydroxyphenylalanine, or 2-amino-3(4-hydroxyphenyl)-propanoic acid, is one of the 20 amino acids that are used by cells to synthesize proteins. ... Phenylalanine is one of the standard amino acids. ... For other uses, see Vitamin C (disambiguation). ... Serotonin (pronounced ) (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesized in serotonergic neurons in the central nervous system (CNS) and enterochromaffin cells in the gastrointestinal tract of animals including humans. ... Pyridoxine Pyridoxal phosphate Vitamin B6 is a water-soluble vitamin. ... Yohimbine, also known under the outdated names quebrachin, aphrodin, corynine, yohimvetol, and hydroergotocin, is the principal alkaloid of the bark of the West-African tree Pausinystalia yohimbe Pierre (formerly Corynanthe yohimbe), family Rubiaceae (Madder family). ... Acidosis is an increased acidity (i. ... Selegiline (l-deprenyl, Eldepryl® or Anipryl® [veterinary]) is a drug used for the treatment of early-stage Parkinsons disease and senile dementia. ... MAO-B is an abbreviation for monoamine oxidase B. There are 2 varieties of monoamine oxidase, which are MAO-A and MAO-B. MAO-A mainly breaks down the neurochemicals serotonin and norepinephrine, whereas MAO-B mainly breaks down the neurochemicals dopamine and phenylethylamine. ... Tolcapone, an inhibitor of catechol-O-methyltransferase (COMT), is used in the treatment of Parkinson’s disease as an adjunct to levodopa/carbidopa therapy. ... Catechol-O-methyl transferase (COMT) (EC 2. ... Working memory is a theoretical framework within cognitive psychology that refers to the structures and processes used for temporarily storing and manipulating information. ...

See also

• Cholinergic
• Neurotransmitter
• Nootropic
• Serotonergic