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Encyclopedia > K. Barry Sharpless
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Karl Barry Sharpless (born April 28, 1941) is an American chemist renowned for his work on organometallic chemistry. Jump to: navigation, search April 28 is the 118th day of the year (119th in leap years) in the Gregorian Calendar, with 247 days remaining. ... Jump to: navigation, search 1941 was a common year starting on Wednesday (link will take you to calendar). ... This is a list of famous chemists: Contents: Top - 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z A Emil Abderhalden, (1877-1950), German chemist Richard Abegg, (1869-1910), German chemist... Chemistry (in Greek: χημεία) is the science of matter that deals with the composition, structure, and properties of substances and with the transformations that they undergo. ...


In 2001 he won the Nobel Prize in Chemistry for his work on stereoselective oxidation reactions (Sharpless epoxidation, Sharpless bishydroxylation, Sharpless aminohydroxylation). This prize was shared with William S. Knowles and Ryoji Noyori (for their work on stereoselective hydrogenation). Currently he spends much of his time promoting click chemistry which are selective, exothermic reactions which occur under mild conditions in water; the most successful variant of which is the alkyne-azide (3 + 2) cycloaddition to form 1,2,3-triazoles. Jump to: navigation, search 2001: A Space Odyssey. ... List of Nobel Prize laureates in Chemistry from 1901 to the present day. ... The most fundamental reactions in chemistry are the redox processes. ... Sharpless epoxidation is a chemical reaction of an allylic alcohol with t-butylperoxide and titanium tetraisopropylate to form an epoxide. ... Sharpless bishydroxylation or asymmetric dihydroxylation (AD) is a chemical reaction of an alkene with osmium tetroxide to form an diol (dialcohol). ... William S. Knowles (born June 1, 1917) is a American chemist. ... Ryoji Noyori (野依良治) (born September 3, 1938) won the Nobel Prize in Chemistry in 2001. ... Jump to: navigation, search Hydrogenation is a chemical reaction in which unsaturated bonds between carbon atoms are reduced by attachment of a hydrogen atom to each carbon. ... Click chemistry is a concept introduced by K. Barry Sharpless in 2001 and describes chemistry tailored to generate substances fast and reliable by joining small repeating units together in the same way as nature does. ... Alkynes are hydrocarbons that have at least one triple bond between two carbon atoms. ... Jump to: navigation, search An azide is a N3- anion, or a reactive group in organic chemistry where a carbon substituent is attached as RN3. ... The 1,3-dipolar cycloaddition is an organic chemical reaction (specifically, a cycloaddition) between a 1,3-dipole and a dipolarophile mostly a substituted alkene to form a substituted five-membered ring. ...


Sharpless was born in Philadelphia. He graduated from Friends' Central Schoolin 1959. He continued his studies at Dartmouth College and earned his PhD from Stanford University in 1963. He continued post-doctoral work at Stanford University and Harvard University. Philadelphia is a village located in Jefferson County, New York. ... Jump to: navigation, search Friends Central School (FCS) is a Religious Society of Friends (Quaker) school located in Wynnewood, a borough of Lower Merion Township, Pennsylvania. ... For other uses of the name Dartmouth, see Dartmouth Dartmouth College is a small private university in Hanover, New Hampshire, and a member of the Ivy League. ... Jump to: navigation, search For other meanings of Stanford, see Stanford (disambiguation). ... Jump to: navigation, search 1963 was a common year starting on Tuesday (link will take you to calendar). ... Harvard University is a private university in Cambridge, Massachusetts, USA, and a member of the Ivy League. ...


Sharpless has been a professor at the Massachusetts Institute of Technology and Stanford University. He currently holds the W. M. Keck professorship in chemistry at the Scripps Research Institute. Jump to: navigation, search The Massachusetts Institute of Technology, or MIT, is a research and educational institution located in the city of Cambridge, Massachusetts, USA with an endowment of just under six billion dollars, the sixth-largest in the United States. ... Jump to: navigation, search For other meanings of Stanford, see Stanford (disambiguation). ... The Scripps Research Institute, in La Jolla, California is home to notable chemists such as K. Barry Sharpless and P. G. Schultz, as well as neurobiologist Gerald Edelman, and Nobel Laureate Kurt Wurtrich. ...


  Results from FactBites:
 
K. Barry Sharpless - Wikipedia, the free encyclopedia (417 words)
Karl Barry Sharpless (born April 28, 1941) is an American chemist renowned for his work on organometallic chemistry.
Sharpless became professor at the Massachusetts Institute of Technology, Stanford University, and the Scripps Research Institute, where he currently holds the W. Keck professorship in chemistry.
Barry also has only one eye; the other was injured when, an NMR tube exploded in his face while he was observing the work of a graduate student.
C&EN: COVER STORY - IN SITU CLICK CHEMISTRY (2432 words)
Finn, one of Sharpless' collaborators, notes that a practical benefit of the strategy is that detecting a hit (an inhibitor of a protein target) "relies not upon characterizing the target protein's function in the presence of the candidate, but rather on detecting the production of a new small molecule.
According to Sharpless, "The building blocks are effectively orthogonal, within limits, to the typical reactive groups and conditions encountered in enzymes and most other biological systems"--that is, they don't tend to cross-react with biomolecules.
In the nonbiological area, Sharpless, Finn, and coworkers are collaborating with groups led by chemistry professors Paul S. Weiss and Raymond L. Funk of Penn State and James M. Tour of Rice University in an effort to develop surfaces with precise chemical patterns at the nanometer scale.
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