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Encyclopedia > Sporozoite

In the life-cycle of apicomplexan protozoa, sporozoites' are cells that infect new hosts. In the parasites that cause malaria, for instance, the sporozoites are cells that leave the mosquito and enter the liver, where they multiply. Cells infected with sporozoites burst, releasing merozoites.


  Results from FactBites:
 
MAEBL Is Essential for Malarial Sporozoite Infection of the Mosquito Salivary Gland -- Kariu et al. 195 (10): 1317 -- ... (4004 words)
Because sporozoite infection of the mosquito salivary glands
The infectivities of maebl(-) sporozoites to the vertebrate
Plasmodium gallinaceum: sporozoite invasion of Aedes aegypti salivary glands is inhibited by anti-gland antibodies and by lectins.
Plasmodium sporozoite biology in the mosquito and vertebrate host (536 words)
Sporozoites develop in oocysts on the midgut wall of infected mosquitoes, are released into the hemocoel and invade salivary glands where they wait to be injected into a vertebrate host during the mosquito’s bloodmeal.
Mosquitoes infected with sporozoites transgenic for β-galactosidase were allowed to probe on a mouse’s ear which was then removed and incubated with X-gal to reveal the injected sporozoites which stain blue.
The basis of sporozoite arrest in the liver is likely the binding between its major surface protein, the circumsporozoite protein (CSP) and heparan sulfate proteoglycans (HSPGs) on the hepatocyte surface.
  More results at FactBites »


 

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